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Why One Brain Circuit Collapses First in Alzheimer’s – New Study/Science Updates



Abstract Glitch BrainVirginia Tech scientists are probing how mitochondrial stress and calcium overload may cause Alzheimer’s to strike memory circuits first, offering clues to the disease’s earliest breakdown. One of the first parts of the brain affected by Alzheimer’s disease is the entorhinal cortex — a region that plays a big role in memory, spatial navigation, and […]



Summary

Virginia Tech researchers are investigating how mitochondrial stress and calcium overload in brain cells may initiate Alzheimer’s disease. They are focusing on the entorhinal cortex, a brain region crucial for memory and spatial navigation, which is among the first areas affected by Alzheimer’s. The study aims to understand how these cellular malfunctions impact this specific brain region, potentially causing the earliest memory deficits observed in Alzheimer’s patients. This research could reveal novel targets for early intervention and prevention strategies by identifying the initial mechanisms of Alzheimer’s-related memory loss.

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Dr AF Saeed

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