T cells engineered to target a shared β-catenin mutation eradicate solid tumors in mice Summary Genetically engineered T cells targeting a specific mutation in the β-catenin protein have shown remarkable success in eradicating solid tumors Read More
Tags :Tumors
Researchers have discovered that brain cancer cells reprogram their sugar metabolism, a vulnerability that can be exploited in mice to impede tumor growth and enhance therapeutic outcomes. Glioblastomas are the most aggressive type of malignant Read More
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Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer
Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma Summary Glioblastoma, a deadly brain cancer, often evades immune responses. This research explores a new strategy to boost immunosurveillance by targeting necrotic Read More
Education, Research & Positions
Therapeutic vaccination against HPV-related tumors: Study shows nanoparticles make difference
Researchers from the German Cancer Research Center (DKFZ) have collaborated with the SILVACX project group at Heidelberg University to develop a therapeutic vaccination concept that can mobilize the immune system to target cancer cells. The Read More
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Evaluating CAR-T cells from neurofibromatosis type 1 (NF1) patients for
Evaluating CAR-T cells from neurofibromatosis type 1 (NF1) patients for targeting AXL in malignant peripheral nerve sheath tumors associated with NF1 Summary This research investigates the potential of CAR-T cell therapy to treat malignant peripheral nerve Read More
Supercharged NK cells: a unique population of NK cells capable of differentiating stem cells and lysis of MHC class I high differentiated tumors Summary A unique population of natural killer (NK) cells, termed “supercharged NK Read More
A drug that acts on a notoriously hard-to-target protein shows promise in a cat oral cancer clinical trial. It may someday help human patients, too. Summary A new drug targeting a difficult-to-reach protein has Read More
Education, Research & Positions
Mitochondrial Enzyme Sensitizes Solid Tumors to Immunotherapy – New Study
Tumors adapt to their environment to avoid detection. As different cancer treatments progress, tumors mutate and become resistant. Various markers are expr Summary Tumors are adept at evading detection and treatment by adapting to their Read More
Education, Research & Positions
TCR-engineered T cells targeting a shared β-catenin mutation eradicate solid
Nature Immunology, Published online: 27 August 2025; doi:10.1038/s41590-025-02252-1 TCR-T cells are T cells engineered to express a specific T cell receptor. Here the authors present a TCR-T cell that targets CTNNB1-S37F, Read More
GD2: hopes and challenges for the treatment of pediatric patients with tumors of the central nervous system Summary GD2 ganglioside, highly expressed in several pediatric central nervous system (CNS) tumors like neuroblastoma and medulloblastoma, presents Read More
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