Tumors are heterogenous masses of cells that rapidly divide. Many cells have different mutations, functions, and ways to avoid immune cell detection and dr Summary Tumors are complex and heterogenous masses of cells characterized by Read More
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A neomorphic protein interface catalyzes covalent inhibition of RASG12D aspartic
Science, Volume 389, Issue 6758, July 2025. Summary Without specific content from the described issue of Science, I can only provide a general summary based on the journal’s known characteristics. Science, Volume 389, Issue 6758, published in July 2025, likely Read More
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LARP4-mediated hypertranslation drives T cell dysfunction in tumors – New
LARP4-mediated hypertranslation drives T cell dysfunction in tumors Summary LARP4, an RNA-binding protein, plays a significant role in tumor-induced T cell dysfunction. Researchers discovered that within tumors, T cells exhibit increased LARP4 expression. This Read More
Pancreatic cancer is deadly; only about 10% of patents live over five years after they are diagnosed. Patients are typically treated with several options, Summary Pancreatic cancer is a devastating disease with a very low five-year Read More
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Metabolic reprogramming via FOXP3 engineering: A Novel strategy to enhance
Metabolic reprogramming via FOXP3 engineering: A Novel strategy to enhance CAR-T cell efficacy in solid tumors Summary Engineering CAR-T cells with the transcription factor FOXP3 can reprogram their metabolism to improve effectiveness against solid tumors. Read More
Science, Volume 388, Issue 6754, Page 1357-1358, June 2025. Summary Without knowing the specific content of Science, Volume 388, Issue 6754, pages 1357-1358, I can only offer a general summary based on typical journal articles. This issue of Science likely Read More
An AI system called iSeg is reshaping radiation oncology by automatically outlining lung tumors in 3D as they shift with each breath. Trained on scans from nine hospitals, the tool matched expert clinicians, flagged cancer Read More
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TRPV1 inhibition sensitizes tumors to PD-1 blockade by reversing resistance
TRPV1 inhibition sensitizes tumors to PD-1 blockade by reversing resistance to CTL-mediated killing Summary TRPV1 inhibition can enhance the effectiveness of PD-1 blockade immunotherapy in treating tumors. Tumors can develop resistance to cytotoxic T lymphocyte (Read More
Barriers and solutions for CAR-T therapy in solid tumors Summary CAR-T cell therapy, a revolutionary cancer treatment, faces significant barriers in solid tumors compared to blood cancers. These hurdles include poor CAR-T cell trafficking to Read More
Scientists spot mitochondria traveling through “bridges” into nearby cancer cells Summary A new study reveals that mitochondria, the powerhouses of cells, can travel between cells, specifically from healthy cells to cancerous ones. Researchers observed mitochondria Read More
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