Nature Reviews Immunology, Published online: 03 September 2025; doi:10.1038/s41577-025-01218-6 The dual nature of non-polymorphic MHC-E as a ligand for innate receptors and as an antigen-presenting protein raises the possibility of new, universally effective Read More
Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma Summary Glioblastoma, a deadly brain cancer, often evades immune responses. This research explores a new strategy to boost immunosurveillance by targeting necrotic Read More
Evaluating CAR-T cells from neurofibromatosis type 1 (NF1) patients for targeting AXL in malignant peripheral nerve sheath tumors associated with NF1 Summary This research investigates the potential of CAR-T cell therapy to treat malignant peripheral nerve Read More
Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8+ T cells Summary Targeting STAT3 specifically in neutrophils, a type of white blood cell, significantly hinders tumor progression, according to this research. Read More
Nature Immunology, Published online: 27 August 2025; doi:10.1038/s41590-025-02252-1 TCR-T cells are T cells engineered to express a specific T cell receptor. Here the authors present a TCR-T cell that targets CTNNB1-S37F, Read More
Targeting LINC01711 in FAP+ cancer-associated fibroblasts overcomes lactate-mediated immunosuppression and enhances anti-PD-1 efficacy in lung adenocarcinoma Summary Targeting LINC01711 in cancer-associated fibroblasts (CAFs) expressing fibroblast activation protein (FAP) shows promise in overcoming immunosuppression in lung Read More
Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment Summary Cancer cells often produce high levels of lactic acid, creating an immunosuppressive microenvironment. This study investigates targeting the MondoA-TXNIP pathway in this lactic acid-rich Read More
Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer Summary Pancreatic cancer often resists immunotherapy, and this resistance is linked to elevated levels of spermine, a polyamine involved in cell growth and survival. Researchers Read More
Targeting the roots of myeloid malignancies with T cell receptors Summary Targeting myeloid malignancies, like leukemia, remains challenging due to disease heterogeneity and relapse risks. A promising approach focuses on using T cell receptors (TCRs) Read More
A novel chimeric antigen receptor T-cell therapy targeting CD84 for the treatment of acute myeloid and T-cell lymphoblastic leukemias Summary A novel CAR-T cell therapy targeting CD84 is showing promise for treating acute myeloid leukemia (Read More
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