screens Archives

CRISPR screens identify STUB1 as an inhibitor of cytokine signaling

Dr AF Saeed Dr AF Saeed 22nd August 2025

Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02247-y Using in vivo CRISPR–Cas9 screens of CD8+ T cells in a melanoma model, we identified STUB1 as an inhibitor of T cell-mediated antitumor immunity. Read More

Education, Research & Positions

Ancestry Bias Could Cause CRISPR Screens to Veer Off-target –

Dr AF Saeed Dr AF Saeed 15th July 2025

Current CRISPR guide RNAs are designed based on European reference genomes, leading to false-negative results in cells from people with African ancestry. Summary Current CRISPR guide RNAs, crucial for precise gene editing, are primarily designed Read More

Education, Research & Positions

Human neuron subtype programming via single-cell transcriptome-coupled patterning screens –

Dr AF Saeed Dr AF Saeed 10th July 2025

Science, Volume 389, Issue 6756, July 2025. Summary Without any specific articles or content details from the described issue of Science, I can only provide a very general summary. Science, Volume 389, Issue 6756, published in July 2025, likely features a Read More