The endogenous T cell landscape is reshaped by CAR-T cell therapy and predicts treatment response in multiple myeloma Summary CAR-T cell therapy for multiple myeloma significantly alters the patient’s existing T cell population. This Read More
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Education, Research & Positions
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates
Nature Immunology, Published online: 15 September 2025; doi:10.1038/s41590-025-02280-x Wang and colleagues show that an AI-assisted designed peptide obstructs GSDMD pores and inhibits IL-1β and IL-18 release and pyroptosis. Summary A study published in Read More
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Bacterial toxins rewire the <i>trans</i>-Golgi network to activate the inflammatory
Nature Immunology, Published online: 09 September 2025; doi:10.1038/s41590-025-02278-5 Cholesterol-dependent cytolysins produced by diverse bacterial pathogens are internalized by host cells and translocate to the trans-Golgi network (TGN). They remodel the TGN into a Read More
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Anti-PD-1 treatment response is associated with the influx of circulating
Anti-PD-1 treatment response is associated with the influx of circulating myeloid and T-cell subsets into the metastatic melanoma tumor microenvironment Summary Anti-PD-1 immunotherapy response in metastatic melanoma is linked to specific immune cell changes within Read More
In the last two decades, scientists have been working to understand if and how sex is correlated to immune response. Previous reports have shown that women Summary Over the past two decades, research has investigated Read More
Malaria is a life-threatening illness spread through mosquitos. According to the World Health Organization (WHO), in 2023 there were over 200 million cases Summary Malaria, a mosquito-borne illness, remains a significant global health threat. In 2023, the World Read More
Education, Research & Positions
Novel Antibody Response Improves Immunotherapy in Cancer Patients – New
Cancer treatment has progressed over the last century. Specifically, the advent of immunotherapy has revolutionized how physicians treat patients. The goal Summary Cancer treatment has dramatically evolved, particularly with the rise of immunotherapy. Immunotherapy aims Read More
As deforestation and climate change threaten to transform the Amazon, there is growing concern that the ecosystem may be reaching an irreversible tipping point, beyond which self-reinforcing feedback loops would lock the system in a Read More
Education, Research & Positions
Personalized circulating tumor DNA dynamics inform survival and response to
Personalized circulating tumor DNA dynamics inform survival and response to immune checkpoint blockade in recurrent/metastatic head and neck cancer Summary This study investigates the utility of personalized circulating tumor DNA (ctDNA) monitoring in patients Read More
Education, Research & Positions
The epiMelanoma test enables plasma-based detection of melanoma and prediction
The epiMelanoma test enables plasma-based detection of melanoma and prediction of immunotherapy response Summary The epiMelanoma test is a blood-based diagnostic tool offering a non-invasive method for melanoma detection and prediction of response to immunotherapy. Read More
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