Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results Summary The AMPLIFY-201 phase 1 trial evaluated a novel lymph node-targeted vaccine targeting the mKRAS mutation in patients with pancreatic and Read More
Pembrolizumab plus axitinib versus sunitinib for advanced clear cell renal cell carcinoma: 5-year survival and biomarker analyses of the phase 3 KEYNOTE-426 trial Summary The KEYNOTE-426 trial investigated pembrolizumab plus axitinib versus sunitinib for advanced clear Read More
Science, Volume 389, Issue 6759, Page 521-525, July 2025. Summary Without knowing the actual content of the Science article, I can provide a general summary structure. This July 2025 issue of Science (Volume 389, Issue 6759, pages 521-525) likely presents original Read More
University of Sussex – Brighton and Sussex Medical School<br />Salary: £25,733 to £29,179 per annum, pro rata if part time. Grade 4 Read more… Credits: jobs.ac.uk DisclaimerRead More
The oncolytic adenovirus Ad-TD-nsIL12 in primary or progressive pediatric IDH wild-type diffuse intrinsic pontine glioma results of two phase I clinical trials Summary Two Phase I clinical trials evaluated the safety and efficacy of Ad-TD-nsIL12, Read More
Human organs-on-chips and organoids offer new alternatives to animals for drug development, but there is still a long way to go. Summary Human organ-on-chips and organoids are emerging as promising alternatives to animal testing in Read More
Neoadjuvant chemoradiotherapy plus sintilimab in pMMR/MSS rectal cancer patients with PD-L1 TPS ≥ 1% or CPS ≥ 1: an open-label, prospective, phase II study Summary This phase II study explored the efficacy of adding sintilimab (an anti-PD-1 immunotherapy) Read More
The James Webb Space Telescope has given astronomers a stunning new window into the history of galaxies like our own Milky Way. By analyzing 111 edge-on galaxies, researchers discovered that galaxies form in two main stages: Read More
Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial Summary This phase 1 clinical trial investigated the safety and efficacy of intracerebroventricular (ICV) administration of bivalent CAR T cells Read More
Sintilimab and anlotinib with gemcitabine plus cisplatin in advanced biliary tract cancer: SAGC a randomized phase 2 trial Summary The SAGC trial, a randomized phase 2 study, investigated the efficacy of sintilimab (a PD-1 inhibitor) and anlotinib (Read More
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