GPRC5D Bispecific antibody talquetamab-induced dizziness-ataxia syndrome, clinical presentation and management- a case series Summary This case series highlights a newly recognized side effect of talquetamab, a GPRC5D-targeting bispecific antibody used to treat multiple Read More
A novel chimeric antigen receptor T-cell therapy targeting CD84 for the treatment of acute myeloid and T-cell lymphoblastic leukemias Summary A novel CAR-T cell therapy targeting CD84 is showing promise for treating acute myeloid leukemia (Read More
Surprising role of CMV in shaping outcomes of immunotherapy for melanoma — chronic infection yields favourable survival Summary Cytomegalovirus (CMV), a common chronic virus, surprisingly improves immunotherapy outcomes in melanoma patients. Research suggests that individuals with Read More
Combining MCL-1 inhibition and CD37-directed chimeric antigen receptor T cells as an effective strategy to target T-cell lymphoma Summary Combining MCL-1 inhibition with CD37-directed CAR T-cell therapy shows promise for treating T-cell lymphoma. Read More
Manufacturing of CRISPR-edited primary mouse CAR T cells for cancer immunotherapy Summary CRISPR-Cas9 technology can enhance CAR T-cell immunotherapy by improving T-cell function and targeting specificity. This study focuses on a streamlined manufacturing process for Read More
Anti-cancer effect of interleukin-2 fused to flagellin expressed by tumor-targeting Salmonella Summary Researchers explored a novel cancer therapy using tumor-targeting Salmonella bacteria. They engineered the bacteria to express a fusion protein combining interleukin-2 (IL-2), an Read More
The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer Summary Hormone receptor-positive (HR+) breast cancer, while treatable, often develops resistance to endocrine therapy. Emerging research explores combining radiation therapy with immunotherapy to Read More
Swansea University – Faculty of Medicine, Health and Life Science<br />Salary: UKRI standard rate Read more… Credits: jobs.ac.uk DisclaimerRead More
T cell engagers: expanding horizons in oncology and beyond Summary T cell engagers (TCEs) are a promising class of immunotherapies harnessing the power of T cells to target and destroy cancer cells. These bispecific antibodies Read More
Endogenous T cell responses to fusion-derived neoantigens in pediatric acute leukemias Summary Pediatric acute leukemias, particularly those with fusion oncogenes, can generate unique neoantigens derived from the fusion point. Research has shown that the immune Read More
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