The endogenous T cell landscape is reshaped by CAR-T cell therapy and predicts treatment response in multiple myeloma Summary CAR-T cell therapy for multiple myeloma significantly alters the patient’s existing T cell population. This Read More
Tags :Oncology
Education, Research & Positions
Next-generation T cell immunotherapies engineered with CRISPR base and prime
Next-generation T cell immunotherapies engineered with CRISPR base and prime editing: challenges and opportunities Summary CRISPR base and prime editing offer promising avenues for enhancing T cell immunotherapies by precisely modifying the T cell genome. Read More
Education, Research & Positions
Enhanced patient selection with quantitative continuous scoring of PD-L1 expression
Enhanced patient selection with quantitative continuous scoring of PD-L1 expression for IO treatment in metastatic NSCLC Summary Quantitative, continuous scoring of PD-L1 expression offers improved patient selection for immunotherapy (IO) treatment in metastatic non-small cell Read More
Education, Research & Positions
EchoBack-CAR T cells: a sonogenetic solution to the persistent challenges
EchoBack-CAR T cells: a sonogenetic solution to the persistent challenges of solid tumor immunotherapy Summary EchoBack-CAR T cells offer a novel approach to solid tumor immunotherapy by addressing key limitations of traditional CAR T-cell therapies. Read More
Education, Research & Positions
Downregulation of MICA/MICB improves cell persistence and clinical activity of
Downregulation of MICA/MICB improves cell persistence and clinical activity of NKG2DL CAR T-cells in patients with relapsed or refractory acute myeloid leukemia or myelodysplastic neoplasia Summary CAR T-cell therapy targeting NKG2D ligands (Read More
Scientists have uncovered how rogue DNA rings may help spark glioblastoma at its earliest stages. An international research team has shown that rogue rings of DNA that exist outside chromosomes, called extrachromosomal DNA, or ecDNA, Read More
Education, Research & Positions
Modulating the PPARγ pathway upregulates NECTIN4 and enhances chimeric antigen
Modulating the PPARγ pathway upregulates NECTIN4 and enhances chimeric antigen receptor (CAR) T cell therapy in bladder cancer Summary Activation of the PPARγ pathway shows promise in improving CAR T cell therapy for bladder cancer. Read More
Education, Research & Positions
Plasmapheresis facilitates soluble BCMA clearance and contributes to reversing primary
Plasmapheresis facilitates soluble BCMA clearance and contributes to reversing primary resistance to anti-BCMA immunotherapy in multiple myeloma Summary Plasmapheresis, a procedure that filters blood, has shown promise in overcoming resistance to anti-BCMA immunotherapies for multiple Read More
The findings challenge long-standing assumptions about therapy-related cancers. They also highlight how drug actions can substitute for genetic changes in tumor development. An international team of researchers, including Prof. Kirsten Kübler from the Berlin Read More
Education, Research & Positions
This Widely-Used Antidepressant Could Be a Powerful New Weapon Against
Antidepressants help immune cells fight cancer. They may improve therapy effectiveness. A commonly prescribed antidepressant may also strengthen the body’s defenses against cancer, according to new research from UCLA. The study, published in Cell, Read More
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