Nature Immunology, Published online: 11 August 2025; doi:10.1038/s41590-025-02237-0 CD4+ T cells migrate from the gut and adipose tissue to the brain parenchyma, in mouse and human, transmitting information on diet and microbiome to Read More
Tags :Neuroimmunology
Nature Immunology, Published online: 24 July 2025; doi:10.1038/s41590-025-02205-8 Single-cell spatial proteomics paired with chromatin accessibility mapping identifies a diverse range of human microglial immune states. In Alzheimer’s disease, hippocampal microglia tend to Read More
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Spatial proteomics of Alzheimer’s disease-specific human microglial states – New
Nature Immunology, Published online: 22 July 2025; doi:10.1038/s41590-025-02203-w In this Resource paper, the authors use MIBI spatial proteomics to map microglial cell states in brains from cognitively normal humans and those with Alzheimer’Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02216-5 Neurons protect against fibrosis Summary New research published in Nature Immunology reveals a surprising role for neurons in preventing fibrosis. The study demonstrates that neurons, Read More
Nature Immunology, Published online: 19 June 2025; doi:10.1038/s41590-025-02184-w The liver portal area has emerged as an important region controlling liver homeostasis and diseases. Tissue macrophages in this region exert immune homeostatic function by Read More
Nature Immunology, Published online: 26 June 2025; doi:10.1038/s41590-025-02194-8 We show that mutations in the CSF1R gene, which cause the rare neurodegenerative disease ALSP, lead to the loss and abnormal activation of microglia. Read More
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Mutations in the human <i>CSF1R</i> gene impact microglia’s maintenance of
Nature Immunology, Published online: 26 June 2025; doi:10.1038/s41590-025-02195-7 Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is a neurodegenerative disorder caused by pathogenic CSF1R mutations. Here the authors find that microglial loss Read More
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Granzyme K<sup>+</sup> CD8 T cells slow tauopathy progression by targeting
Nature Immunology, Published online: 24 June 2025; doi:10.1038/s41590-025-02198-4 McGavern and colleagues identified a CD8+ T cell population that expresses GZMK in ʽtau-richʼ brains, where it may play a protective role against neurodegeneration. Summary Read More
Nature Immunology, Published online: 25 June 2025; doi:10.1038/s41590-025-02209-4 We identify a clonally expanded subset of granzyme K-expressing CD8+ T cells that establish residency in the central nervous system, where they target microglia and Read More
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Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry
Nature Reviews Immunology, Published online: 24 June 2025; doi:10.1038/s41577-025-01201-1 White et al. show that microbiota-specific T cells are licensed by gut inflammation to infiltrate the central nervous system, where cross-reactivity with self-antigens leads Read More
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