myeloid Archives

Targeting the roots of myeloid malignancies with T cell receptors

Dr AF Saeed Dr AF Saeed 21st August 2025

Targeting the roots of myeloid malignancies with T cell receptors Summary Targeting myeloid malignancies, like leukemia, remains challenging due to disease heterogeneity and relapse risks. A promising approach focuses on using T cell receptors (TCRs) Read More

Education, Research & Positions

A novel chimeric antigen receptor T-cell therapy targeting CD84 for

Dr AF Saeed Dr AF Saeed 6th August 2025

A novel chimeric antigen receptor T-cell therapy targeting CD84 for the treatment of acute myeloid and T-cell lymphoblastic leukemias Summary A novel CAR-T cell therapy targeting CD84 is showing promise for treating acute myeloid leukemia (Read More

Education, Research & Positions

The MicroRNA miR-223 Constrains Colitis-associated Tumorigenesis by Limiting Myeloid Cell

Dr AF Saeed Dr AF Saeed 28th June 2025

Abstract Aberrant intestinal inflammation plays a critical role in the development of colitis-associated colorectal cancer (CAC), yet the mechanisms controlling tumor development by the myeloid immune compartment are not fully understood. Although altered microRNA expression Read More

Education, Research & Positions

SIRPα blockade therapy potentiates immunotherapy by inhibiting PD-L1+ myeloid cells

Dr AF Saeed Dr AF Saeed 28th June 2025

SIRPα blockade therapy potentiates immunotherapy by inhibiting PD-L1+ myeloid cells in hepatocellular carcinoma Summary SIRPα blockade enhances immunotherapy effectiveness in hepatocellular carcinoma (HCC) by targeting a specific subset of myeloid cells. These myeloid cells, which Read More