Epigenetic modulation with nanosatellite triggers tumoricidal immunity for hepatocellular carcinoma treatment Summary Researchers have developed a novel approach to treat hepatocellular carcinoma (HCC) by combining epigenetic modulation with nanosatellite delivery to trigger an anti-tumor immune Read More
Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellular vesicles Summary This research explores a novel approach to combat lung metastasis and recurrence by using CAR (Chimeric Antigen Read More
AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progression Summary Prostate cancer progression can be fueled by a specific type of macrophage called AR+TREM2+ macrophages. These macrophages, characterized by the androgen receptor (AR) Read More
Nature Immunology, Published online: 25 July 2025; doi:10.1038/s41590-025-02217-4 Sajti and colleagues identify TREM2 as a critical factor in myeloid cells in response to hyperoxia-induced lung injury in neonates, finding that TREM2 deficiency protects Read More
Agonistic immune checkpoint regulator may harm the heart Summary Agonistic immune checkpoint regulators (AICRs), designed to enhance anti-tumor immunity, may pose a risk to the heart. While AICRs like CD40 agonists are showing promise in Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02214-7 Train your histones Summary A newly published Nature Immunology article highlights the potential for “training” histones, proteins around which DNA is wrapped, to influence immune Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02191-x Tumor-associated macrophages are pivotal in control over solid tumors. Here the authors show that these macrophages express chemosensors that detect lipid variants in the tumor Read More
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