microenvironment Archives

Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment –

Dr AF Saeed Dr AF Saeed 22nd August 2025

Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment Summary Cancer cells often produce high levels of lactic acid, creating an immunosuppressive microenvironment. This study investigates targeting the MondoA-TXNIP pathway in this lactic acid-rich Read More

Education, Research & Positions

Chimeric exosomes-derived immunomodulator restoring lymph nodes microenvironment for sensitizing TNBC

Dr AF Saeed Dr AF Saeed 2nd August 2025

Chimeric exosomes-derived immunomodulator restoring lymph nodes microenvironment for sensitizing TNBC immunotherapy Summary This research explores a novel approach to improve immunotherapy response in Triple-Negative Breast Cancer (TNBC) using chimeric exosomes. These engineered exosomes, derived from Read More

Education, Research & Positions

Dual targeting of tumoral cells and immune microenvironment by blocking

Dr AF Saeed Dr AF Saeed 14th July 2025

Dual targeting of tumoral cells and immune microenvironment by blocking the IL-33/IL1RL1 pathway Summary Blocking the IL-33/IL1RL1 pathway presents a promising dual approach for cancer therapy. IL-33, released by stressed or Read More

Education, Research & Positions

Targeting ribosomes reprograms the tumour microenvironment and augments cancer immunotherapy

Dr AF Saeed Dr AF Saeed 11th July 2025

Targeting ribosomes reprograms the tumour microenvironment and augments cancer immunotherapy Summary Targeting ribosomes, the protein synthesis machinery of cells, can significantly alter the tumor microenvironment (TME) and enhance cancer immunotherapy. Dysfunctional ribosomes in cancer cells Read More

Education, Research & Positions

Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment

Dr AF Saeed Dr AF Saeed 1st July 2025

Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation Summary Metabotropic glutamate receptor 4 (mGluR4) signaling in dendritic cells (DCs) significantly alters the tumor microenvironment. Activation of mGluR4, a glutamate Read More