Nature Reviews Immunology, Published online: 08 September 2025; doi:10.1038/s41577-025-01219-5 Functional and metabolic properties of innate-like T cells — namely, iNKT cells, MAIT cells and some γδ T cells — differ from those of conventional T cells. Read More
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UGCG and the glycosphingolipid rheostat: a metabolic checkpoint governing immune
UGCG and the glycosphingolipid rheostat: a metabolic checkpoint governing immune activation and tumor immune evasion Summary UDP-glucose ceramide glucosyltransferase (UGCG) controls the “glycosphingolipid rheostat,” a metabolic checkpoint pivotal in immune responses and tumor immune evasion. Read More
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Researchers discover new microprotein that controls metabolic health in mouse
Like bees breathing life into gardens, providing pollen and making flowers blossom, little cellular machines called mitochondria breathe life into our bodies, buzzing with energy as they produce the fuel that powers each of our Read More
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Genomic convergence in hibernating mammals elucidates the genetics of metabolic
Science, Volume 389, Issue 6759, Page 494-500, July 2025. Summary I lack the ability to access specific issues of scientific journals from the future. As such, I cannot provide a summary of the content described. To summarize, I Read More
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Conserved noncoding cis elements associated with hibernation modulate metabolic and
Science, Volume 389, Issue 6759, Page 501-507, July 2025. Summary Without knowing the specific content of the Science issue mentioned, it’s impossible to provide a truly accurate summary. However, I can offer a general summary based on Read More
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Exercise induces metabolic changes in the gut microbiota that enhance
Nature Reviews Immunology, Published online: 28 July 2025; doi:10.1038/s41577-025-01217-7 Exercise promotes changes in the gut microbiota that enhance anti-tumour T cell responses. Summary A Nature Reviews Immunology article (published July 28, 2025) highlights the connection Read More
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Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis
Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis and its therapeutic implications for targeted treatment strategies Summary Colorectal cancer (CRC) cells exhibit metabolic reprogramming, primarily through aerobic glycolysis, also known as the Warburg Read More
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Metabolic alterations driven by LDHA in CD8 + T cells promote immune
Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC Summary Lung cancer cells often evade the immune system by manipulating CD8+ T cells, the body’s primary Read More
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Metabolic reprogramming via FOXP3 engineering: A Novel strategy to enhance
Metabolic reprogramming via FOXP3 engineering: A Novel strategy to enhance CAR-T cell efficacy in solid tumors Summary Engineering CAR-T cells with the transcription factor FOXP3 can reprogram their metabolism to improve effectiveness against solid tumors. Read More
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