Engineering TCR-preserved allogeneic CAR-T cells: leveraging cancer immune evasion principles to establish T-cell tolerance Summary Engineering allogeneic CAR-T cells that retain their T cell receptor (TCR) could overcome challenges of current CAR-T therapies. By understanding Read More
SARDH in the 1-C metabolism sculpts the T-cell fate and serves as a potential cancer therapeutic target Summary SARAH (Sarcosine Dehydrogenase) plays a crucial role in 1-carbon (1-C) metabolism, a pathway vital for cell growth Read More
Proteogenomic approach to immunopeptidomics of ovarian tumors identifies shared peptide vaccine candidates Summary A proteogenomic approach was used to analyze ovarian tumors, combining genomic and proteomic data with immunopeptidomics to identify potential shared peptide vaccine Read More
The gut microbiota in cancer immunity and immunotherapy Summary The gut microbiota plays a crucial role in shaping both local and systemic immune responses, significantly impacting cancer development and response to immunotherapy. Specific bacterial species Read More
Oncolytic virus-mediated p53 activation boosts the antitumor immunity of a p53-transduced dendritic cell vaccine Summary This research explores combining oncolytic viruses and p53-enhanced dendritic cell (DC) vaccines to improve cancer immunotherapy. Specifically, DCs Read More
CD2 augmentation enhances CAR-T-cell efficacy via immunological synapse remodeling and T-cell exhaustion mitigation Summary Augmenting CAR-T cells with CD2 enhances their anti-tumor efficacy by improving the immunological synapse. This involves restructuring the synapse architecture for Read More
Metabolic reprogramming via FOXP3 engineering: A Novel strategy to enhance CAR-T cell efficacy in solid tumors Summary Engineering CAR-T cells with the transcription factor FOXP3 can reprogram their metabolism to improve effectiveness against solid tumors. Read More
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