Manufacturing of CRISPR-edited primary mouse CAR T cells for cancer immunotherapy Summary CRISPR-Cas9 technology can enhance CAR T-cell immunotherapy by improving T-cell function and targeting specificity. This study focuses on a streamlined manufacturing process for Read More
Tags :immunotherapy
Education, Research & Positions
A hexamerization-enhanced, Fc-silenced agonistic CD27 antibody amplifies T-cell effector functions
A hexamerization-enhanced, Fc-silenced agonistic CD27 antibody amplifies T-cell effector functions as single agent and in combination with PD-1 blockade Summary This research presents a novel CD27 agonistic antibody engineered for enhanced activity. By promoting hexamerization (Read More
Education, Research & Positions
The untapped potential of radiation and immunotherapy for hormone receptor-positive
The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer Summary Hormone receptor-positive (HR+) breast cancer, while treatable, often develops resistance to endocrine therapy. Emerging research explores combining radiation therapy with immunotherapy to Read More
ICANS risk model in CD19 CAR-T therapy: insights from serum and CSF cytokine profiling Summary This study explores the predictive power of the Immune Cell-Associated Neurotoxicity Syndrome (ICANS) risk model in CD19 CAR-T therapy patients Read More
Humoral determinants of checkpoint immunotherapy Summary Humoral factors, like antibodies and complement proteins, play a crucial but often overlooked role in checkpoint immunotherapy efficacy. Beyond T-cell activation, checkpoint inhibitors can influence antibody-dependent cellular cytotoxicity (ADCC) Read More
Education, Research & Positions
Endogenous T cell responses to fusion-derived neoantigens in pediatric acute
Endogenous T cell responses to fusion-derived neoantigens in pediatric acute leukemias Summary Pediatric acute leukemias, particularly those with fusion oncogenes, can generate unique neoantigens derived from the fusion point. Research has shown that the immune Read More
Education, Research & Positions
Resolving the structural basis of therapeutic antibody function in cancer
Resolving the structural basis of therapeutic antibody function in cancer immunotherapy with RESI Summary RESI, or Relative Entropy Scanning of Interactions, is a computational approach that identifies key amino acid residues in antibody-antigen interactions crucial Read More
Education, Research & Positions
Immunological features of clear-cell renal-cell carcinoma and resistance to immune
Immunological features of clear-cell renal-cell carcinoma and resistance to immune checkpoint inhibitors Summary Clear-cell renal cell carcinoma (ccRCC) is characterized by immune infiltration, but often exhibits resistance to immune checkpoint inhibitors (ICIs). Several factors contribute Read More
Education, Research & Positions
LARP4-mediated hypertranslation drives T cell dysfunction in tumors – New
LARP4-mediated hypertranslation drives T cell dysfunction in tumors Summary LARP4, an RNA-binding protein, plays a significant role in tumor-induced T cell dysfunction. Researchers discovered that within tumors, T cells exhibit increased LARP4 expression. This Read More
Education, Research & Positions
Immunotherapy for diffuse gastric cancer: challenges and new avenues –
Immunotherapy for diffuse gastric cancer: challenges and new avenues Summary Immunotherapy offers promise for treating diffuse gastric cancer (DGC), a particularly aggressive subtype with limited therapeutic options. However, DGC presents unique challenges, including low immunogenicity Read More
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