Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02221-8 During late gestation, unconventional intraepithelial αβ T cells migrate from the gut to the mammary gland to remodel the tissue for lactation and enhance its mucosal Read More
Tags :immunology
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02218-3 Here Ramanan and colleagues provide an analysis of mammary T cells during late pregnancy and lactation. This revealed an increase in intraepithelial lymphocytes in the Read More
Nature Reviews Immunology, Published online: 29 July 2025; doi:10.1038/s41577-025-01206-w Modification of the nucleotide pool is emerging as key to innate immunity in animals, plants and bacteria. This Review explains how immune pathways conserved Read More
Exercise induces metabolic changes in the gut microbiota that enhance
Nature Reviews Immunology, Published online: 28 July 2025; doi:10.1038/s41577-025-01217-7 Exercise promotes changes in the gut microbiota that enhance anti-tumour T cell responses. Summary A Nature Reviews Immunology article (published July 28, 2025) highlights the connection Read More
The impact of genetic immune disorders on infections including COVID-19,
Nature Immunology, Published online: 28 July 2025; doi:10.1038/s41590-025-02225-4 Cui et al. discuss new molecular and cellular insights underlying the pathogenesis of rare human diseases that arise from genetic inborn errors of immunity. Summary Read More
Nature Immunology, Published online: 25 July 2025; doi:10.1038/s41590-025-02244-1 Adoptive T cell therapies show limited efficacy against solid tumors owing to T cell exhaustion within the tumor microenvironment. A study now reveals that dysregulated Read More
Nature Immunology, Published online: 25 July 2025; doi:10.1038/s41590-025-02242-3 When dendritic cells migrate through narrow gaps, they transiently assemble a mechanosensitive actin structure in front of their nucleus. This structure pushes outward against the Read More
Nature Immunology, Published online: 25 July 2025; doi:10.1038/s41590-025-02217-4 Sajti and colleagues identify TREM2 as a critical factor in myeloid cells in response to hyperoxia-induced lung injury in neonates, finding that TREM2 deficiency protects Read More
The transcription complex p52–ETS1 is essential for germinal center formation
Nature Immunology, Published online: 25 July 2025; doi:10.1038/s41590-025-02236-1 Tergaonkar and colleagues identify a noncanonical interaction between the NF-κB transcription factor family member p52 and the ETS family member ETS1. They find that Read More
Nature Reviews Immunology, Published online: 24 July 2025; doi:10.1038/s41577-025-01203-z This Review by Poirier highlights the intrinsic mechanisms that protect stem cells from infection. The author also explains how stem cell populations in different Read More