Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumour immunity and tumour escape Summary Neoadjuvant immunotherapy in melanoma is revealing crucial insights into anti-tumor immunity and tumor escape mechanisms. Pre-treatment tumor samples allow for detailed analysis Read More
Nature Immunology, Published online: 22 September 2025; doi:10.1038/s41590-025-02285-6 The authors spatially and functionally map innate lymphoid cells in the human female genital tract at homeostasis, uncovering tissue-specific and subset-specific distribution and functions, and Read More
Nature Immunology, Published online: 19 September 2025; doi:10.1038/s41590-025-02294-5 The artificial intelligence (AI)-designed peptide SK56 blocks mature gasdermin D pores, delaying pyroptosis and inflammatory cytokine release. This reduces dendritic cell hyperactivation and prevents Read More
Nature Immunology, Published online: 19 September 2025; doi:10.1038/s41590-025-02283-8 Here the authors show how the DNA-sensing cGAS–STING pathway activates NF-κB and inflammatory gene expression with delayed kinetics via post-Golgi endolysosomal signaling. Summary Read More
Nature Immunology, Published online: 18 September 2025; doi:10.1038/s41590-025-02275-8 The effector fates of innate lymphoid cells (ILCs) are epigenetically imprinted early in ontogeny through the selective loss of DNA methylation at signature genes encoding Read More
Nature Immunology, Published online: 18 September 2025; doi:10.1038/s41590-025-02261-0 Wang and colleagues show that specific DNA methylation profiles mark the ILC progenitors (ILCP) that would differentiate into ILC1, ILC2 or ILC3 subsets. Summary Wang Read More
Feeding the animals a high fiber diet reduced Alzheimer ’s-related frailty, including tremors. The gut houses the body’s largest population of immune cells. A new study from the Buck Institute has revealed that in Read More
Nature Immunology, Published online: 16 September 2025; doi:10.1038/s41590-025-02284-7 CD4+ T follicular helper (TFH) cells that develop in response to a range of pathogens share aspects of a common gene signature. However, cytokine environments, Read More
Nature Immunology, Published online: 16 September 2025; doi:10.1038/s41590-025-02281-w Here Iliev et al. review the interactions between the microbiota and the mucosal immune system from infancy to adulthood, highlighting the impact on health and Read More
Nature Immunology, Published online: 15 September 2025; doi:10.1038/s41590-025-02268-7 Here the authors spatially map human pediatric low-grade gliomas using imaging mass cytometry, focusing on immunosuppressive myeloid cell populations and their functionality in tumor–immune Read More
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