Nature Immunology, Published online: 26 June 2025; doi:10.1038/s41590-025-02194-8 We show that mutations in the CSF1R gene, which cause the rare neurodegenerative disease ALSP, lead to the loss and abnormal activation of microglia. Read More
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Mutations in the human <i>CSF1R</i> gene impact microglia’s maintenance of
Nature Immunology, Published online: 26 June 2025; doi:10.1038/s41590-025-02195-7 Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is a neurodegenerative disorder caused by pathogenic CSF1R mutations. Here the authors find that microglial loss Read More
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