Nature Reviews Immunology, Published online: 16 June 2025; doi:10.1038/s41577-025-01193-y Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate Read More
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Multiscale dynamic immunomodulation by a nanoemulsified Trojan-TLR7/8 adjuvant for robust
Multiscale dynamic immunomodulation by a nanoemulsified Trojan-TLR7/8 adjuvant for robust protection against heterologous pandemic and endemic viruses Summary A novel nanoemulsion adjuvant, encapsulating a TLR7/8 agonist, was developed for enhanced and broad-spectrum antiviral immunity. This “Read More
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The rapidly evolving paradigm of neoadjuvant immunotherapy across cancer types
The rapidly evolving paradigm of neoadjuvant immunotherapy across cancer types Summary Neoadjuvant immunotherapy (NAIT), administering immunotherapy before surgery, is rapidly changing cancer treatment. Early trials show promising results, including higher rates of pathological complete response (Read More
Nature Immunology, Published online: 25 June 2025; doi:10.1038/s41590-025-02209-4 We identify a clonally expanded subset of granzyme K-expressing CD8+ T cells that establish residency in the central nervous system, where they target microglia and Read More
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Innate immune responses to pathogens at the maternal–fetal interface
Nature Reviews Immunology, Published online: 18 June 2025; doi:10.1038/s41577-025-01191-0 During pregnancy, innate immune mechanisms at the maternal–fetal interface are important for protecting the developing fetus from pathogens. However, excessive immune activation can Read More
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Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry
Nature Reviews Immunology, Published online: 24 June 2025; doi:10.1038/s41577-025-01201-1 White et al. show that microbiota-specific T cells are licensed by gut inflammation to infiltrate the central nervous system, where cross-reactivity with self-antigens leads Read More
Nature Reviews Immunology, Published online: 25 June 2025; doi:10.1038/s41577-025-01202-0 A preprint by Srivastava et al. reports that C19S modification of insulin, which occurs in response to a stressed microenvironment, promotes pro-inflammatory T Read More
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