CRISPR Archives

CRISPR screens identify STUB1 as an inhibitor of cytokine signaling

Dr AF Saeed Dr AF Saeed 22nd August 2025

Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02247-y Using in vivo CRISPR–Cas9 screens of CD8+ T cells in a melanoma model, we identified STUB1 as an inhibitor of T cell-mediated antitumor immunity. Read More

Education, Research & Positions

CRISPR Cultivates an Arabidopsis Rose Rainbow – New Study/Science Updates

Dr AF Saeed Dr AF Saeed 31st July 2025

Arabidopsis blooms take on whimsical forms and surprising colors, merging gene editing with artistic flair. Summary Gene editing is being used to create Arabidopsis (a small flowering plant) blooms with unusual shapes and vibrant colors, Read More

Education, Research & Positions

Ancestry Bias Could Cause CRISPR Screens to Veer Off-target –

Dr AF Saeed Dr AF Saeed 15th July 2025

Current CRISPR guide RNAs are designed based on European reference genomes, leading to false-negative results in cells from people with African ancestry. Summary Current CRISPR guide RNAs, crucial for precise gene editing, are primarily designed Read More