The liver metabolizes dietary galactose to fuel antitumour T cell immunity Summary Dietary galactose, often overlooked, plays a crucial role in fueling anti-tumor T cell responses, particularly when metabolized in the liver. The liver’s Read More
Tags :Cell Biology
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Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a
Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a small molecule sensitizing glioblastoma to anti-PD1 Summary Glioblastoma (GBM) is a deadly brain cancer with limited treatment options, and immunotherapy’s effectiveness is often hindered. Read More
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ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF
ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation Summary ULBP2 CAR-T cells show promise in improving gastric cancer immunotherapy by targeting and killing tumor cells and simultaneously disrupting the tumor microenvironment. The Read More
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Anti-cancer effect of interleukin-2 fused to flagellin expressed by tumor-targeting
Anti-cancer effect of interleukin-2 fused to flagellin expressed by tumor-targeting Salmonella Summary Researchers explored a novel cancer therapy using tumor-targeting Salmonella bacteria. They engineered the bacteria to express a fusion protein combining interleukin-2 (IL-2), an Read More
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The untapped potential of radiation and immunotherapy for hormone receptor-positive
The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer Summary Hormone receptor-positive (HR+) breast cancer, while treatable, often develops resistance to endocrine therapy. Emerging research explores combining radiation therapy with immunotherapy to Read More
ICANS risk model in CD19 CAR-T therapy: insights from serum and CSF cytokine profiling Summary This study explores the predictive power of the Immune Cell-Associated Neurotoxicity Syndrome (ICANS) risk model in CD19 CAR-T therapy patients Read More
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MARCO expression on myeloid-derived suppressor cells is essential for their
MARCO expression on myeloid-derived suppressor cells is essential for their differentiation and immunosuppression Summary Myeloid-derived suppressor cells (MDSCs) require MARCO expression to properly differentiate and exert their immunosuppressive functions. MARCO, a scavenger receptor, plays a Read More
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Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis
Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis and its therapeutic implications for targeted treatment strategies Summary Colorectal cancer (CRC) cells exhibit metabolic reprogramming, primarily through aerobic glycolysis, also known as the Warburg Read More
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IFNγ augments TKI efficacy by alleviating protein unfolding stress to
IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma Summary Interferon-gamma (IFNγ) enhances the effectiveness of tyrosine kinase inhibitors (TKIs) in treating hepatocellular carcinoma (HCC) by mitigating protein Read More
Education, Research & Positions
Impaired autophagy by cepharanthine induces immunogenic cell death and enhances
Impaired autophagy by cepharanthine induces immunogenic cell death and enhances anti-PD-1 response in MSS-type colorectal cancer Summary Cepharanthine, a drug known to impair autophagy, shows promise in enhancing anti-PD-1 immunotherapy for MSS-type colorectal cancer (CRC), Read More
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