Real-time PCR enables faster Mycoplasma detection to meet rigorous cell therapy safety standards and reduce quality control-related workflow delays. Summary Real-time PCR is a rapid method for detecting Mycoplasma contamination, crucial for ensuring the safety Read More
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Education, Research & Positions
Bacillus Calmette-Guerin induces CD8+ T cell infiltration and suppresses tumor
Bacillus Calmette-Guerin induces CD8+ T cell infiltration and suppresses tumor progression in microsatellite stable colorectal cancer by downregulating ARID1A Summary Bacillus Calmette-Guerin (BCG) treatment demonstrates promise in combating microsatellite stable (MSS) colorectal cancer. The Read More
The endogenous T cell landscape is reshaped by CAR-T cell therapy and predicts treatment response in multiple myeloma Summary CAR-T cell therapy for multiple myeloma significantly alters the patient’s existing T cell population. This Read More
Education, Research & Positions
Next-generation T cell immunotherapies engineered with CRISPR base and prime
Next-generation T cell immunotherapies engineered with CRISPR base and prime editing: challenges and opportunities Summary CRISPR base and prime editing offer promising avenues for enhancing T cell immunotherapies by precisely modifying the T cell genome. Read More
Education, Research & Positions
Engineered Prime Editors with Improved Precision Could Provide Safer Cell
Researchers from MIT have incorporated several modifications to prime editing systems, making them up to 60 times more precise. Summary MIT researchers have significantly improved the precision of prime editing, a gene-editing technology. By implementing multiple Read More
Education, Research & Positions
Epigenetic imprinting in innate lymphoid cell precursors directs the lineage
Nature Immunology, Published online: 18 September 2025; doi:10.1038/s41590-025-02261-0 Wang and colleagues show that specific DNA methylation profiles mark the ILC progenitors (ILCP) that would differentiate into ILC1, ILC2 or ILC3 subsets. Summary Wang Read More
Joseph Gall was posthumously recognized for the societal impacts of his basic research in molecular biology, guided by his profound love of nature. Summary Joseph Gall, a pioneering molecular biologist, was honored posthumously for the Read More
Nature Immunology, Published online: 16 September 2025; doi:10.1038/s41590-025-02284-7 CD4+ T follicular helper (TFH) cells that develop in response to a range of pathogens share aspects of a common gene signature. However, cytokine environments, Read More
The 2020 Nobel Prize in Chemistry was awarded for the development of CRISPR/Cas9, a method also known as “gene scissors,” which enables researchers to better understand how human cells function and stay healthy. Researchers at Read More
Education, Research & Positions
Downregulation of MICA/MICB improves cell persistence and clinical activity of
Downregulation of MICA/MICB improves cell persistence and clinical activity of NKG2DL CAR T-cells in patients with relapsed or refractory acute myeloid leukemia or myelodysplastic neoplasia Summary CAR T-cell therapy targeting NKG2D ligands (Read More
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