The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer Summary Hormone receptor-positive (HR+) breast cancer, while treatable, often develops resistance to endocrine therapy. Emerging research explores combining radiation therapy with immunotherapy to Read More
T cell engagers: expanding horizons in oncology and beyond Summary T cell engagers (TCEs) are a promising class of immunotherapies harnessing the power of T cells to target and destroy cancer cells. These bispecific antibodies Read More
Immunological features of clear-cell renal-cell carcinoma and resistance to immune checkpoint inhibitors Summary Clear-cell renal cell carcinoma (ccRCC) is characterized by immune infiltration, but often exhibits resistance to immune checkpoint inhibitors (ICIs). Several factors contribute Read More
Combination of pembrolizumab and radiotherapy induces systemic antitumor immune responses in immunologically cold non-small cell lung cancer Summary A study demonstrates that combining pembrolizumab, an immunotherapy drug, with radiotherapy can trigger systemic anti-tumor immune responses Read More
MARCO expression on myeloid-derived suppressor cells is essential for their differentiation and immunosuppression Summary Myeloid-derived suppressor cells (MDSCs) require MARCO expression to properly differentiate and exert their immunosuppressive functions. MARCO, a scavenger receptor, plays a Read More
Microbiota-driven antitumour immunity mediated by dendritic cell migration Summary The gut microbiota plays a crucial role in shaping anti-tumor immunity. Specific gut bacteria stimulate the migration of dendritic cells (DCs) from the gut to tumor Read More
Multomic analysis reveals the potential of LAG3 as a prognostic and immune biomarker and its validation in osteosarcoma Summary A multomic analysis of osteosarcoma (OS) reveals LAG3’s potential as a significant prognostic and immune Read More
Targeting ribosomes reprograms the tumour microenvironment and augments cancer immunotherapy Summary Targeting ribosomes, the protein synthesis machinery of cells, can significantly alter the tumor microenvironment (TME) and enhance cancer immunotherapy. Dysfunctional ribosomes in cancer cells Read More
Targeting mTORC2 in lung squamous cell carcinoma improves anti-tumor immunity through the PSGL-1-VISTA axis Summary Targeting mTORC2 in lung squamous cell carcinoma (LUSC) enhances anti-tumor immunity by modulating the PSGL-1-VISTA pathway. Specifically, mTORC2 Read More
Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC Summary Lung cancer cells often evade the immune system by manipulating CD8+ T cells, the body’s primary Read More
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