Polyclonal expansion of functional tumor-reactive lymphocytes infiltrating glioblastoma for personalized cell therapy Summary This research explores leveraging the body’s own immune system to fight glioblastoma, a deadly brain cancer. The study focuses on expanding Read More
Cascade amplification of therapeutic payloads for cancer immunotherapy Summary “Cascade amplification of therapeutic payloads” in cancer immunotherapy refers to strategies designed to enhance the efficacy of delivered drugs or immunomodulatory agents within the tumor microenvironment. Read More
Targeting LINC01711 in FAP+ cancer-associated fibroblasts overcomes lactate-mediated immunosuppression and enhances anti-PD-1 efficacy in lung adenocarcinoma Summary Targeting LINC01711 in cancer-associated fibroblasts (CAFs) expressing fibroblast activation protein (FAP) shows promise in overcoming immunosuppression in lung Read More
Personalized circulating tumor DNA dynamics inform survival and response to immune checkpoint blockade in recurrent/metastatic head and neck cancer Summary This study investigates the utility of personalized circulating tumor DNA (ctDNA) monitoring in patients Read More
Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment Summary Cancer cells often produce high levels of lactic acid, creating an immunosuppressive microenvironment. This study investigates targeting the MondoA-TXNIP pathway in this lactic acid-rich Read More
Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer Summary Pancreatic cancer often resists immunotherapy, and this resistance is linked to elevated levels of spermine, a polyamine involved in cell growth and survival. Researchers Read More
The bispecific innate cell engager AFM28 eliminates CD123+ leukemic stem and progenitor cells in AML and MDS Summary AFM28, a bispecific innate cell engager targeting CD123 and CD16A, demonstrates promising results in eliminating leukemic Read More
Targeting the roots of myeloid malignancies with T cell receptors Summary Targeting myeloid malignancies, like leukemia, remains challenging due to disease heterogeneity and relapse risks. A promising approach focuses on using T cell receptors (TCRs) Read More
GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/phase 2 trial Summary This Phase 1/Phase 2 trial investigates the safety and efficacy of GD2-targeted CAR T cell therapy in patients with high-risk neuroblastoma, a Read More
GD2: hopes and challenges for the treatment of pediatric patients with tumors of the central nervous system Summary GD2 ganglioside, highly expressed in several pediatric central nervous system (CNS) tumors like neuroblastoma and medulloblastoma, presents Read More
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