Promoting the therapeutic potential of interleukin-7 (IL-7) by expression in viral vectors Summary Viral vectors offer a promising avenue for delivering interleukin-7 (IL-7), a cytokine crucial for T cell survival and proliferation, to harness its Read More
T cells engineered to target a shared β-catenin mutation eradicate solid tumors in mice Summary Genetically engineered T cells targeting a specific mutation in the β-catenin protein have shown remarkable success in eradicating solid tumors Read More
Modulating the PPARγ pathway upregulates NECTIN4 and enhances chimeric antigen receptor (CAR) T cell therapy in bladder cancer Summary Activation of the PPARγ pathway shows promise in improving CAR T cell therapy for bladder cancer. Read More
Plasmapheresis facilitates soluble BCMA clearance and contributes to reversing primary resistance to anti-BCMA immunotherapy in multiple myeloma Summary Plasmapheresis, a procedure that filters blood, has shown promise in overcoming resistance to anti-BCMA immunotherapies for multiple Read More
Publisher Correction: GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial Summary A phase 1/2 clinical trial investigated the safety and efficacy of GD2-targeting CAR T cells in children and young adults with Read More
CD160+CD8+ T cells for improved immunotherapy Summary CD160+CD8+ T cells are a subset of cytotoxic T lymphocytes (CTLs) with enhanced antitumor activity. CD160, an activating receptor, distinguishes these cells and contributes to their Read More
CD160 dictates anti-PD-1 immunotherapy resistance by regulating CD8+ T cell exhaustion in colorectal cancer Summary CD160, a surface receptor on CD8+ T cells, plays a crucial role in resistance to anti-PD-1 immunotherapy in colorectal cancer (Read More
Integration of humanized ROBO1 CAR in PD-1 locus in natural killer cells delivers synergistic tumor-killing effect against non-small cell lung cancer Summary Engineering natural killer (NK) cells with chimeric antigen receptors (CARs) targeting tumor-associated antigens Read More
Efficacy and safety of induction immunotherapy plus chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a meta-analysis Summary This meta-analysis investigates the efficacy and safety of adding induction immunotherapy to chemotherapy for locoregionally advanced nasopharyngeal Read More
Nature Immunology, Published online: 05 September 2025; doi:10.1038/s41590-025-02269-6 The pre-T cell receptor is essential for T cell development. It is also an emerging immunotherapy target. Summary The pre-T cell receptor (pre-TCR) is crucial Read More
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