Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results Summary The AMPLIFY-201 phase 1 trial evaluated a novel lymph node-targeted vaccine targeting the mKRAS mutation in patients with pancreatic and Read More
GPRC5D Bispecific antibody talquetamab-induced dizziness-ataxia syndrome, clinical presentation and management- a case series Summary This case series highlights a newly recognized side effect of talquetamab, a GPRC5D-targeting bispecific antibody used to treat multiple Read More
Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a small molecule sensitizing glioblastoma to anti-PD1 Summary Glioblastoma (GBM) is a deadly brain cancer with limited treatment options, and immunotherapy’s effectiveness is often hindered. Read More
Epigenetic modulation with nanosatellite triggers tumoricidal immunity for hepatocellular carcinoma treatment Summary Researchers have developed a novel approach to treat hepatocellular carcinoma (HCC) by combining epigenetic modulation with nanosatellite delivery to trigger an anti-tumor immune Read More
Investigating the correlation between IDO1/PD-L1 expression or co-expression and EGFR/KRAS gene mutations in advanced NSCLC Summary This study explores the relationship between IDO1 and PD-L1 expression (both individually and together) and the presence Read More
Defects in antigen processing and presentation: mechanisms, immune evasion and implications for cancer vaccine development Summary Defects in antigen processing and presentation (APP) mechanisms are critical for immune surveillance and cancer control. These defects, arising Read More
Nanotechnology for immuno-oncology Summary Nanotechnology offers promising solutions for immuno-oncology, enhancing cancer immunotherapy’s effectiveness. Nanoparticles can improve drug delivery to tumors and immune cells, overcoming limitations of traditional methods like poor solubility and systemic Read More
Sorafenib-treated Th9 cells exhibit superior anti-tumor effect in lung metastasis Summary Sorafenib, a multi-kinase inhibitor, enhances the anti-tumor activity of Th9 cells (a type of T helper cell) in lung metastasis models. Specifically, sorafenib treatment Read More
The gut microbiota in cancer immunity and immunotherapy Summary The gut microbiota plays a crucial role in shaping both local and systemic immune responses, significantly impacting cancer development and response to immunotherapy. Specific bacterial species Read More
Surprising role of CMV in shaping outcomes of immunotherapy for melanoma — chronic infection yields favourable survival Summary Cytomegalovirus (CMV), a common chronic virus, surprisingly improves immunotherapy outcomes in melanoma patients. Research suggests that individuals with Read More
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