Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumour immunity and tumour escape Summary Neoadjuvant immunotherapy in melanoma is revealing crucial insights into anti-tumor immunity and tumor escape mechanisms. Pre-treatment tumor samples allow for detailed analysis Read More
Slaying the pre-TCR beast Summary "Slaying the pre-TCR beast" likely refers to overcoming challenges and inefficiencies in traditional Request for Change (RFC) processes before implementing a more streamlined and automated Technical Change Request (Read More
Bacillus Calmette-Guerin induces CD8+ T cell infiltration and suppresses tumor progression in microsatellite stable colorectal cancer by downregulating ARID1A Summary Bacillus Calmette-Guerin (BCG) treatment demonstrates promise in combating microsatellite stable (MSS) colorectal cancer. The Read More
Next-generation T cell immunotherapies engineered with CRISPR base and prime editing: challenges and opportunities Summary CRISPR base and prime editing offer promising avenues for enhancing T cell immunotherapies by precisely modifying the T cell genome. Read More
Enhanced patient selection with quantitative continuous scoring of PD-L1 expression for IO treatment in metastatic NSCLC Summary Quantitative, continuous scoring of PD-L1 expression offers improved patient selection for immunotherapy (IO) treatment in metastatic non-small cell Read More
A novel GM-CSF-encoding oncolytic adenovirus induces profound autophagy and promotes viral replication to enhance anti-tumor efficacy Summary A genetically modified oncolytic adenovirus expressing GM-CSF enhances anti-tumor efficacy by inducing significant autophagy. This autophagy, unexpectedly, promotes Read More
Promoting the therapeutic potential of interleukin-7 (IL-7) by expression in viral vectors Summary Viral vectors offer a promising avenue for delivering interleukin-7 (IL-7), a cytokine crucial for T cell survival and proliferation, to harness its Read More
T cells engineered to target a shared β-catenin mutation eradicate solid tumors in mice Summary Genetically engineered T cells targeting a specific mutation in the β-catenin protein have shown remarkable success in eradicating solid tumors Read More
Modulating the PPARγ pathway upregulates NECTIN4 and enhances chimeric antigen receptor (CAR) T cell therapy in bladder cancer Summary Activation of the PPARγ pathway shows promise in improving CAR T cell therapy for bladder cancer. Read More
Plasmapheresis facilitates soluble BCMA clearance and contributes to reversing primary resistance to anti-BCMA immunotherapy in multiple myeloma Summary Plasmapheresis, a procedure that filters blood, has shown promise in overcoming resistance to anti-BCMA immunotherapies for multiple Read More
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