Microbiota-driven antitumour immunity mediated by dendritic cell migration Summary The gut microbiota plays a crucial role in shaping anti-tumor immunity. Specific gut bacteria stimulate the migration of dendritic cells (DCs) from the gut to tumor Read More
Targeting gut microbiota and arginase boosts MEK inhibitors’ enhancement of antitumour immunity via MHC-I upregulation in colorectal cancer Summary MEK inhibitors, while promising for colorectal cancer (CRC) treatment, often face limited efficacy. This study reveals Read More
Single-cell spatial analysis with Xenium reveals anti-tumour responses of CXCL13 + T and CXCL9+ cells after radiotherapy combined with anti-PD-L1 therapy Summary A study using single-cell spatial analysis with the Xenium platform investigated the effects of Read More
Bispecific killer cell engager-secreting CAR-T cells redirect natural killer specificity to enhance antitumour responses Summary Genetically engineered CAR-T cells can be modified to secrete bispecific killer cell engagers (BiKEs) targeting both tumor-associated antigens and NK Read More
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