Caerin 1.1/1.9 interfere KHDRBS1-DDX5 regulatory axis to induce IL-18 mediated pyroptosis in a HeLa cell tumour model



Summary

Caerin 1.1 and 1.9, peptides, disrupt the KHDRBS1-DDX5 regulatory axis in HeLa cancer cells. This disruption triggers IL-18 mediated pyroptosis, a form of programmed cell death characterized by inflammation. Essentially, the peptides target a specific protein network critical for cell survival, leading to an inflammatory cell death pathway in this cancer cell model. The study suggests Caerin 1.1/1.9 as potential therapeutic candidates for cancer treatment by inducing pyroptosis through this mechanism.

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