Nature Immunology, Published online: 25 March 2026; doi:10.1038/s41590-026-02486-7
Our work reveals functional heterogeneity among interstitial macrophages, showing that distinct chemokine programs determine immune cell positioning and interactions within lung tumors. Interstitial macrophage niches support anti-tumor tertiary lymphoid structure formation and lymphocyte recruitment, but they also recruit pro-tumorigenic macrophages to the tumor microenvironment. Moreover, monocyte-derived dendritic cells migrate to tumor-draining lymph nodes, where they prime immunosuppressive responses. Blockade of this migration improved dendritic cell-based vaccination.
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