A genetic set-point for natural killer cells – Immunology Research

296Immunology


Nature Immunology, Published online: 16 March 2026; doi:10.1038/s41590-026-02474-x

Variation in HLA class I signal peptides sets the strength of NKG2A-mediated education of CD56bright natural killer (NK) cells, revealing a genetically encoded ‘set point’ for innate immune fitness and linking NK cell tuning to protection from cancer and inflammatory disease.



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