Nature Immunology, Published online: 09 March 2026; doi:10.1038/s41590-026-02460-3
Fibroblasts and macrophages have classically been viewed as engaging in a one-way supportive relationship in which fibroblasts sustain macrophage survival. Emerging evidence now challenges this paradigm by demonstrating a bidirectional regulatory circuit in which macrophages actively restrain fibroblast activation to preserve tissue integrity.
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