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      An inhibitory RNA checkpoint in TLR7 and TLR8 – Immunology Research

      296Immunology


      Nature Immunology, Published online: 04 March 2026; doi:10.1038/s41590-026-02450-5

      Activation of the nucleic acid-sensing receptors TLR7 and TLR8 must be tightly regulated, as aberrant activation can result in autoimmune disease. Data now show that endogenous RNA fragments actively impose an allosteric checkpoint on receptor activation.



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