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      Metabolic adaptation in CD4<sup>+</sup> T cells promotes immunosuppression in sepsis – Immunology Research

      296Immunology


      Nature Immunology, Published online: 15 January 2026; doi:10.1038/s41590-025-02403-4

      Immune dysfunction and aberrant metabolic remodeling are hallmarks of critical illness including sepsis. Metabolic adaptation of CD4+ T cells is now shown to contribute to immunosuppression and poor clinical outcomes in critical illness.



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