Antigen-specific Treg cells induce infectious tolerance



Summary

Antigen-specific regulatory T cells (Tregs) can induce “infectious tolerance,” a powerful mechanism where Tregs not only suppress immune responses against a specific antigen but also convert other immune cells into suppressor cells. This process involves Tregs initially suppressing the primary immune response against a target antigen. These newly suppressed cells then gain suppressive function themselves and can migrate to other locations, spreading the tolerogenic effect. This amplifies the initial suppression and generates a more robust and long-lasting tolerance, potentially mitigating autoimmune diseases and enhancing transplant tolerance. The antigen specificity of Tregs allows for targeted immune suppression, minimizing broad immunosuppression.

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