Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellular vesicles



Summary

This research explores a novel approach to combat lung metastasis and recurrence by using CAR (Chimeric Antigen Receptor) macrophages. The key innovation lies in generating these therapeutic macrophages in-situ, meaning directly within the lungs, using messenger RNA (mRNA) delivered by small extracellular vesicles. This method aims to avoid the challenges associated with traditional CAR-T cell therapies, such as systemic toxicity and limited tumor penetration. The in-situ generation of CAR macrophages promises a targeted and efficient way to eliminate metastatic lung cancer cells and prevent relapse, offering a potentially safer and more effective treatment strategy.

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