Mice with a diverse human T cell receptor repertoire selected on multiple HLA class I molecules



Summary

Mice were engineered to express a diverse range of human T cell receptors (TCRs) selected based on their ability to recognize multiple human leukocyte antigen (HLA) class I molecules. This allows the mice to generate human-like T cell responses against HLA-presented antigens. The development of these mice provides a valuable platform for studying human T cell immunity, including responses to infections, cancers, and autoimmune diseases. They can be used to evaluate the efficacy of immunotherapies and vaccines designed to target HLA-restricted T cell responses, offering a significant advantage over traditional mouse models.

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