Evaluating CAR-T cells from neurofibromatosis type 1 (NF1) patients for targeting AXL in malignant peripheral nerve sheath tumors associated with NF1



Summary

This research investigates the potential of CAR-T cell therapy to treat malignant peripheral nerve sheath tumors (MPNSTs) associated with neurofibromatosis type 1 (NF1). MPNSTs are aggressive cancers with limited treatment options, and NF1 patients are at increased risk. The study focuses on AXL, a protein often overexpressed in MPNSTs, as a target for CAR-T cells. Researchers are evaluating CAR-T cells derived from NF1 patients for their ability to recognize and kill AXL-expressing MPNST cells. The goal is to determine if CAR-T cells offer a promising and personalized immunotherapeutic approach for these challenging cancers.

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