Anti-PD-1 treatment response is associated with the influx of circulating myeloid and T-cell subsets into the metastatic melanoma tumor microenvironment – New Study
Anti-PD-1 treatment response is associated with the influx of circulating myeloid and T-cell subsets into the metastatic melanoma tumor microenvironment
Summary
Anti-PD-1 immunotherapy response in metastatic melanoma is linked to specific immune cell changes within the tumor. Responders exhibit an increased presence of circulating myeloid cells (like monocytes and dendritic cells) and T-cell subsets within the tumor microenvironment (TME). This influx suggests a crucial role for these immune cells in mediating the anti-tumor effects of PD-1 blockade. Effectively, the recruitment and accumulation of these immune cell populations within the TME appear to be a key factor in determining whether a patient will benefit from anti-PD-1 therapy.
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