This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-incompatible conformation to couple methionine sensing to mTORC1 regulation.
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Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex – Research
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