GPX4 released by ferroptotic cancer cells suppresses dendritic cell maturation and T cell priming by binding to ZP3. Blocking the GPX4-ZP3 interaction restores dendritic activity, boosts cytotoxic T cells, and enhances chemo-, radio-, and immunotherapy efficacy in preclinical cancer models.
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Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors – Research
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