Tumor metabolism selectively enriches Tregs to achieve immunosuppression, but the underlying mechanisms remain unclear. Here, we show that tumor-derived ammonia drives Treg-specific enrichment. Tregs detoxify ammonia via the urea cycle and spermine synthesis, which enhances their function, revealing how Tregs adapt in tumors and suggesting strategies for next-generation cancer immunotherapies.
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Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity – Research
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