In nuclear speckles, sequence-encoded inter-domain attractive and repulsive interactions drive proteins to form hierarchical structures, including size-limited microphases, clusters of microphases, micron-scale double emulsions in protein mixtures, and microphases stabilized by preferential and protein-specific binding to the lncRNA MALAT1.
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Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases – Research
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