Scientists at Gladstone Institutes uncovered a surprising reason why dopamine-producing neurons, crucial for smooth body movements, die in Parkinson’s disease. In mice, when these neurons were kept overactive for weeks, they began to falter, first losing their connections and then dying altogether. This mirrors the selective neuron loss seen in patients, where overworked cells in […]



Summary

Gladstone Institutes researchers found that overactivity in dopamine-producing neurons contributes to cell death in Parkinson’s disease. In mice, prolonged overstimulation led to these neurons losing connections and eventually dying. This mimics the selective neuron loss observed in Parkinson’s patients. The study suggests that excessive activity, rather than other presumed causes, could be a key driver in the disease’s progression, highlighting a potential new target for therapies aimed at reducing neuronal overstimulation and preserving dopamine production.

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