A groundbreaking study has revealed over 200 misfolded proteins in the brains of aging rats with cognitive impairment, far beyond the well-known amyloid and tau plaques. These newly identified proteins don’t form the typical clumps seen under microscopes, making them harder to detect but potentially just as dangerous. Scientists believe these stealthy molecules might be […]



Summary

A new study identified over 200 previously undetected, misfolded proteins in the brains of aging rats with cognitive decline, exceeding the number of known amyloid and tau plaques. These “stealth” proteins don’t form visible clumps, making them difficult to identify, but researchers suspect they play a significant role in cognitive impairment. This discovery suggests that protein misfolding is more complex and widespread in aging brains than previously thought, opening new avenues for understanding and potentially treating age-related cognitive decline.

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