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Engineered telomerase RNA and polygenic scores reveal new insights into telomere biology – New Study/Science Updates



Similar to the way the caps on the ends of a shoelace prevent it from fraying, telomeres—regions of repetitive DNA sequences and a protein structure—protect the tips of chromosomes from damage.



Summary

Telomeres, like shoelace caps, safeguard chromosomes. These repetitive DNA sequences with associated proteins are located at the ends of chromosomes, acting as protective buffers against damage or degradation. Without telomeres, chromosomes would fray and potentially fuse, leading to cellular dysfunction. Telomeres shorten with each cell division, eventually triggering cell aging or programmed cell death when they reach a critical length. Their role in maintaining genomic stability is crucial for cell health and overall organismal well-being.

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Dr AF Saeed

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