Weizmann Institute of Science-led researchers have unveiled a computational workflow that crafts enzymes exhibiting catalytic efficiencies surpassing 100,000 M−1 s−1, achieving performance comparable to natural biocatalysts without extensive refinement.



Summary

Researchers at the Weizmann Institute of Science have developed a groundbreaking computational method for designing highly efficient artificial enzymes. This innovative workflow enables the creation of enzymes with catalytic efficiencies exceeding 100,000 M−1 s−1, rivaling the performance of naturally occurring enzymes. Importantly, this feat is achieved without the need for laborious optimization processes typically associated with enzyme engineering. This development marks a significant advancement in biocatalysis, offering potential for faster and more accessible design of high-performing enzymes for various applications.

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