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Cutting to the core of how 3D structure shapes gene activity – New Study



In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be helpful for learners to begin with the linear presentation of how stretches of DNA form genes, this oversimplification undersells the significance of the genome’s 3D structure.



Summary

Traditional biology education often presents the human genome and DNA linearly, simplifying its complex three-dimensional structure. While this linear representation provides a helpful starting point for understanding gene formation, it fails to capture the full significance of the genome’s organization. The spatial arrangement of DNA within the cell is crucial for regulating gene expression and other cellular processes, making the simplification a significant oversight in understanding the genome’s functionality. Therefore, understanding the 3D structure is vital for a complete picture of genomic function.

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Dr AF Saeed

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