The amount of each of the more than a thousand different glycoproteins in your blood varies widely, with the 10 most abundant glycoproteins accounting for 90% of the total mass. Finding a protein that isn’t in this top 10 is a bit like looking for Waldo if only one rendition of the character remained in a collection of every “Where’s Waldo” comic ever produced.



Summary

Your blood contains a vast array of glycoproteins, but their abundance is highly unequal. The top 10 glycoproteins constitute the vast majority (90%) of the total glycoprotein mass. This means finding a less common glycoprotein is incredibly difficult, akin to searching for the sole remaining Waldo across all “Where’s Waldo” comics. This disparity in abundance presents a significant challenge in identifying and studying these less prevalent, yet potentially important, glycoproteins.

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