Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response



Summary

Pressure-fused biomineral tablets offer a promising approach for sustained interleukin-2 (IL-2) release, enhancing antitumor immune responses. This method involves compressing biominerals into tablets that slowly release IL-2 over extended periods. This prolonged release is crucial, as it avoids the toxicity associated with high-dose IL-2 bolus injections and provides consistent immune stimulation within the tumor microenvironment. The sustained IL-2 delivery effectively promotes the proliferation and activation of cytotoxic T lymphocytes and natural killer cells, key players in eradicating cancer cells. Studies have demonstrated that these tablets significantly reduce tumor growth and improve survival rates in preclinical models by fostering a robust and durable antitumor immunity.

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