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Fatty liver disease induced by maternal obesity is driven by metabolic rewiring of Kupffer cells


Nature Reviews Immunology, Published online: 30 June 2025; doi:10.1038/s41577-025-01205-x

Maternal obesity during pregnancy promotes a form of fatty liver disease in offspring that is dependent on HIF1α-mediated rewiring of Kupffer cell metabolism.



Summary

A Nature Reviews Immunology article published June 30, 2025, reports that maternal obesity during pregnancy induces fatty liver disease in offspring. This condition is linked to alterations in Kupffer cell metabolism, specifically driven by the transcription factor HIF1α. The research highlights how the mother’s obesity influences the developing liver of the child through HIF1α-dependent metabolic reprogramming of Kupffer cells, which are resident macrophages in the liver. This suggests a novel mechanism by which maternal health can impact offspring health and predispose them to metabolic diseases.

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