Job description

Job summary

Dementia is the greatest health challenge of our century.

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.

The UK DRI Centre at Imperial College London has been established to address a medical research area of the highest importance and future impact. As one of seven national centres of excellence embedded in major UK universities, we intend to transform the diagnosis, treatment and care of people with dementias.  The Medical Research Council and charity partners the Alzheimer’s Society and Alzheimer’s Research UK have invested £290m in fulfilment of the ambition identified in the Prime Minister’s 2020 Challenge on Dementia.

The fellowship programme of Dr Raffaella Nativio is focused on defining the epigenetic pathways of healthy aging and age-related neurodegeneration. Epigenetic regulation is a critical player in aging of lower organisms and it represents a potential therapeutically tractable player in age-related diseases. The post-holder will use a combination of high-throughput technologies, coupled with in vivo functional validations to identify epigenetic pathways of stress response in human brain that promote or protect from age-related neurodegeneration.

Duties and responsibilities

The UK DRI is seeking an outstanding post-doctoral researcher interested in tackling a challenging role with considerable scope for independent scientific achievement and personal growth.

You will be result-oriented, with the passion to tackle big problems and a readiness to try out high-risk, high-payoff projects. Outstanding experience in genomics, epigenomics and/or molecular neuroscience are desirable.

Research duties:

  • To take initiative in the planning of research
  • To direct the work of small research teams
  • To identify and develop suitable techniques, and apparatus, for the collection and analysis of data
  • To conduct data analysis
  • To ensure the validity and reliability of data at all times
  • To maintain accurate and complete records of all findings
  • To write reports for submission to research sponsors
  • To present findings to colleagues and at conferences
  • To submit publications to refereed journals
  • To provide mentorship to staff and students
  • To attend relevant workshops and conferences as necessary
  • To develop contacts and research collaborations within the College, the UK DRI and the wider community

Essential requirements

You will require a PhD in biological sciences (molecular biology, biochemistry, neurobiology) or a closely related discipline, or equivalent research, industrial or commercial experience and the knowledge of molecular biology and biochemistry.

You will be expected to help define specific research programmes within this remit and undertake these in conjunction with colleagues in multi-disciplinary teams. Considerable independence is expected, with anticipation of a growing role in leadership of the research. In addition, you will be expected to submit publications to refereed journals and to join in attracting external research funding.

There will be opportunities for supervision of students. Experience in other teaching roles, including lecturing, will be enabled as part of the broad range of career development opportunities that Imperial College makes available to its post-doctoral research staff.

Further information

The contract is offered full time, initially for a fixed term until 31 March 2025

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £35,477 – £38,566 per annum.

Applicants are strongly encouraged to contact Dr Raffaella Nativio for informal discussion about the role r.nativio@imperial.ac.uk

Please also get in touch with her should you have any queries about applying to the role.

For more information about the UK DRI at Imperial, please visit:

http://www.imperial.ac.uk/dementia-research-institute

For technical issues when applying online please email recruitment@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

Apply:

https://www.imperial.ac.uk/jobs/application/MED02137/research-associate-epigenomics-uk-dementia-research-institute/

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