The Laboratory for Molecular Virology and Gene Therapy is renowned for research on HIV nuclear import and integration. This basic research aims at developing strategies for an HIV Cure. In recent years we developed a cutting edge imaging platform that allows visualizing single HIV particles in living cells on their journey through the cell. In this project we want to investigate the role of nuclear import on integration site selection and HIV persistence. LIterature 1. Rocha, S., Hendrix, J., Borrenberghs, D., Debyser, Z., Hofkens, J. (2020). Imaging the Replication of Single Viruses: Lessons Learned from HIV and Future Challenges To Overcome. ACS Nano, 14 (9), 10775-10783. 2. Vansant, G., Chen, H-C., Zorita, E., Trejbalova, K., Miklik, D., Filion, G., Debyser, Z. (2020). The chromatin landscape at the HIV-1 provirus integration site determines viral expression. Nucleic Acids Research, 48 (14), 7801-7817. 3. Bonisch, I.Z., Dirix, L., Lemmens, V., Borrenberghs, D., De Wit, F., Vernaillen, F., Rocha, S., Christ, F., Hendrix, J., Hofkens, J., Debyser, Z. (2020). Capsid-Labelled HIV To Investigate the Role of Capsid during Nuclear Import and Integration. Journal of Virology, 94 (7), Art.No. ARTN e01024-19. 4. De Wit, F., Pillalamarri, S.R., Sebastian-Martin, A., Venkatesham, A., Van Aerschot, A., Debyser, Z. (2019). Design of reverse transcriptase-specific nucleosides to visualize early steps of HIV-1 replication by click labeling. Journal of Biological Chemistry, 294 (31), 11863-11875. 5. Rodriguez-Mora, S., De Witid, F., Garcia-Perez, J., Bermejo, M., Lopez-Huertas, M.R., Mateos, E., Marti, P., Rocha, S., Vigon, L., Christ, F., Debyser, Z., Vilchez, J.J., Coiras, M., Alcami, J. (2019). The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection. Plos Pathogens, 15 (8), Art.No. ARTN e1007958. 6. Borrenberghs, D., Zurnic, I., De Wit, F., Acke, A., Dirix, L., Cereseto, A., Debyser, Z., Hendrix, J. (2019). Post-mitotic BET-induced reshaping of integrase quaternary structure supports wild-type MLV integration. Nucleic Acids Research, 47 (3), 1195-1210. 7. Borrenberghs, D., Dirix, L., De Wit, F., Rocha, S., Blokken, J., De Houwer, S., Gijsbers, R., Christ, F., Hofkens, J., Hendrix, J., Debyser, Z. (2016). Dynamic oligomerization of integrase orchestrates HIV nuclear entry. Scientific Reports, 6, Art.No. 10.1038/srep36485. 8. Vranckx, L.S., Demeulemeester, J., Saleh, S., Boll, A., Vansant, G., Schrijvers, R., Weydert, C., Battivelli, E., Verdin, E., Cereseto, A., Christ, F., Gijsbers, R., Debyser, Z. with Gijsbers, R. (joint last author), Debyser, Z. (2016). LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV. EBiomedicine, 8, 248-264. Website unit

Responsibilities
  • 2 years of postdoctoral fellowship to perform own basic researchon HIV replication and supervise master and PhD students
  • Publication of research results in high impact journals.
  • Participation in international research meetings.
Profile
  • PhD in medicine, biomedical sciences, sciences, pharmaceutical sciences, biology, microbiology, biochemistry…
  • 2 first author publications is recommended as well as 3 letters of reference.
  • Expertise in HIV virology is a strong bonus. 
  • Expertise in confocal microscopy is a bonus
  • Experience in bioinformatics is a bonus.
Offer
  • 2 years of postdoctoral research in fully equipped state of the art research facilities
  • Technical support by core facilities and expert technicians.
  • Application to competitive (inter)national postdoc fellowships is a bonus.
Interested?

For more information please contact Prof. dr. Zeger Debyser, tel.: +32 16 37 40 29, mail: [email protected] can apply for this job no later than February 26, 2021 via the online application toolKU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at [email protected]

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