Job TypeFull-timeTemporaryFull Job Description
The postdoctoral appointees will conduct research on the regulation of the Gli protein TRA-1 in nematodes, and on the evolutionary changes that have shaped that regulation. This work will be supervised by the principal investigator, Ronald Ellis.
This position includes research on projects outlined in two newly-funded grant proposals, the development of new research areas, and the supervision of students and other lab personnel. Presentation of this work through research papers, review articles, and talks at international meetings will be required.
Other duties may be assigned.
If desired, the appointee will be offered the opportunity to gain teaching experience in graduate programs existing within the Graduate School of Biomedical Sciences – Stratford Division, with assistance from the principal investigator. If appropriate, the successful candidate will have the opportunity to transition into independent research endeavors with the intent of becoming a faculty member of the Department of Molecular Biology.
A Ph.D. in Molecular Biology or a related discipline is required. Strength in several of the following areas is needed to be competitive: familiarity with the nematode C. elegans or one of its relatives, classical genetic techniques, mutant screening, reverse genetic approaches, analysis of animal development, and skill with evolutionary and phylogenetic methods. An outstanding record of communicating scientific results through writing and seminars is desired.
The appointee will study the regulation of the Gli protein TRA-1 and its role in sex-determination in the nematodes C. elegans, C. briggsae, C. tropicalis and related species. These studies will focus on the molecular regulatory mechanisms that control TRA-1 activity and its interactions with chromatin factors and with target genes. In addition, comparisons between species will be used to analyze the evolutionary changes that shaped this regulatory pathway, and produced self-fertile hermaphrodites in some species.